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1

The Contributions of Marketing to Strategic Management

E. Ralph Biggadike

Journal:

The Academy of Management Review

Year:

1981

Language:

english

File:

PDF, 490 KB

english, 1981

2

Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodouracil

Borthwick, Alan D., Evans, Derek N., Kirk, Barrie E., Biggadike, Keith, Exall, Anne M., Youds, Peter, Roberts, Stanley M., Knight, David J., Coates, Jonathan A. V.

Journal:

Journal of Medicinal Chemistry

Year:

1990

Language:

english

File:

PDF, 1.11 MB

english, 1990

3

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Arylsulfonamide Groups

Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Butchers, Peter R., Coe, Diane M., Conroy, Richard, Edney, Dean D., Field, Rita N., Ford, Alison J., Guntrip, Stephe

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 478 KB

english, 2009

4

Characterising the pharmacological properties of fluticasone furoate, a novel enhanced-affinity glucocorticoid

Salter, Mark, Biggadike, Keith, West, Michael, Haase, Michael, Gray, David, Farrow, Stuart, Hogger, Petra, Valotis, Anagnostis

Journal:

World Allergy Organization Journal

Year:

2007

Language:

english

File:

PDF, 146 KB

english, 2007

5

ChemInform Abstract: 7-Carbon Mimics of D-Glucose and L-Fucose: Activation by 6R-, and Inactivation by 6S, -6C-Methylglucose of Glycogen Synthase: Inhibition of Glucokinase and/or Glucose-6-phosphatase.

Y. BLERIOT, K. H. SMELT, J. CADEFAU, M. BOLLEN, W. STALMANS, K. BIGGADIKE, L. N. JOHNSON, N. G. OIKONOMAKOS, A. L. LANE, S. CROOK, D. J. WATKIN, G. W. J. FLEET

Journal:

Year:

1997

File:

PDF, 38 KB

1997

6

ChemInform Abstract: The First Example of a 6-C-Aryl-D-glucose: Inhibition of Glucokinase.

Y. BLERIOT, C. R. VEIGHEY, K. H. SMELT, J. CADEFAU, W. STALMANS, K. BIGGADIKE, A. L. LANE, M. MUELLER, D. J. WATKIN, G. W. J. FLEET

Journal:

Year:

1997

File:

PDF, 37 KB

1997

7

ChemInform Abstract: Diastereoselective Resolution of 6-Substituted Glycosides via Enzymatic Hydrolysis.

U. GRABOWSKA, D. A. MACMANUS, K. BIGGADIKE, M. I. BIRD, S. DAVIES, T. GALLAGHER, L. D. HALL, E. N. VULFSON

Journal:

Year:

1998

File:

PDF, 32 KB

1998

8

ChemInform Abstract: Enzymic Glycosylation Using 6-Substituted Glycosides as Donor Substrates: A Novel Route to Functionalized Disaccharides.

David A. MacManus, Urszula Grabowska, Keith Biggadike, Michael I. Bird, Stephen Davies, Evgeny N. Vulfson, Timothy Gallagher

Journal:

Year:

1999

File:

PDF, 35 KB

1999

9

ChemInform Abstract: Novel Glucocorticoid Antedrugs Possessing a C16,17-Fused γ-Lactone Ring.

Keith Biggadike, Sean M. Lynn, Panayiotis A. Procopiou, Rupert E. Shaw, Christopher Williamson

Journal:

Year:

2000

File:

PDF, 34 KB

2000

10

ChemInform Abstract: Novel Glucocorticoid Antedrugs Possessing a 21-(γ-Lactone) Ring.

Richard M. Angell, Keith Biggadike, Rosanne M. Farrell, Stephen S. Flack, Ashley P. Hancock, Wendy R. Irving, Sean M. Lynn, Panayiotis A. Procopiou

Journal:

Year:

2002

File:

PDF, 37 KB

2002

11

7-Carbon mimics of D-glucose and L-fucose: Activation by 6R-, and inactivation by 6S, -6C-methylglucose of glycogen synthase: Inhibition of glucokinase and/or glucose-6-phosphatase

Yves Blériot, Kathryn H. Smelt, Joan Cadefau, Mathieu Bollen, Willy Stalmans, Keith Biggadike, Louise N. Johnson, Nikos G. Oikonomakos, Alexandra L. Lane, Sarah Crook, David J. Watkin, George W.J. Fle

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 279 KB

english, 1996

12

Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists

Keith Biggadike, Matilde Caivano, Margaret Clackers, Diane M. Coe, George W. Hardy, Davina Humphreys, Haydn T. Jones, David House, Annette Miles-Williams, Philip A. Skone, Iain Uings, Vicki Weller, Ia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 753 KB

english, 2009

13

Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity

Hawa Diallo, Davina C. Angell, Heather A. Barnett, Keith Biggadike, Diane M. Coe, Tony W.J. Cooper, Andy Craven, James R. Gray, David House, Torquil I. Jack, Steve P. Keeling, Simon J.F. Macdonald, Ia

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.54 MB

english, 2011

14

Diastereoselective resolution of 6-substituted glycosides via enzymatic hydrolysis

Urszula Grabowska, David A. MacManus, Keith Biggadike, Mike I. Bird, Stephen Davies, Timothy Gallagher, Lee D. Hall, Evgeny N. Vulfson

Journal:

Carbohydrate Research

Year:

1997

Language:

english

File:

PDF, 888 KB

english, 1997

15

Synthesis of chiral crbocyclic nucleosides

Alan D Borthwick, keith Biggadike

Journal:

Year:

1992

Language:

english

File:

PDF, 2.81 MB

english, 1992

16

Enantiospecific synthesis of the potent anti-herpetic carbocyclic 9-(2′deoxy-2′-flouro-β-D-arabinofuranosyl) guanine (+)CAFG from arsiteromycin

Alan D Borthwick, Keith Biggadike, Stuart Holman, C.L. Mo

Journal:

Tetrahedron Letters

Year:

1990

Language:

english

File:

PDF, 193 KB

english, 1990

17

Inhibition of Fucosyl Transferase and Fucosidase by a Rigid Bicyclic Mimic of α-L-Fucose

Annabel R Beacham, Kathryn H Smelt, Keith Biggadike, Christopher J Britten, Lucy Hackett, Bryan G Winchester, Robert J Nash, Rhodri C Griffiths, George W.J Fleet

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 801 KB

english, 1998

18

Photobromination of a bicyclic mimic of α-L-fucose; components for a combinatorial library of rigid fucose analogues

Kathryn H. Smelt, Yves Blériot, Keith Biggadike, Sean Lynn, Alexandra L. Lane, David J. Watkin, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 309 KB

english, 1999

19

Components for a combinatorial library of rigid azabicyclic α-L-fucose mimics: First X-ray crystal structure of a stable monoalkylated triazene formed by hydrogenation of an azide

Kathryn H. Smelt, Amanda J. Harrison, Keith Biggadike, Mathias Müller, Keith Prout, David J. Watkin, George W.J. Fleet

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 302 KB

english, 1999

20

Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines

Alan D. Borthwick, Keith Biggadike, Ian L. Paternoster, Jonathan A.V. Coates, David J. Knight

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 250 KB

english, 1993

21

Structure–activity relationship on human serum paraoxonase (PON1) using substrate analogues and inhibitors

Rakesh S Bargota, Mahmoud Akhtar, Keith Biggadike, David Gani, Rudolf K Allemann

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 146 KB

english, 2003

22

The Effect of Pasture Nitrate Concentration and Concentrate Intake after Turnout on Embryo Growth and Viability in the Lactating Dairy Cow

RA Laven, HJ Biggadike, RD Allison

Journal:

Reproduction in Domestic Animals

Year:

2002

Language:

english

File:

PDF, 307 KB

english, 2002

23

The first example of a 6-C-aryl-d-glucose: Inhibition of glucokinase

Yves Blériot, Clifford R. Veighey, Kathryn H. Smelt, Joan Cadefau, Willy Stalmans, Keith Biggadike, Alexandra L. Lane, Matthias Müller, David J. Watkin, George W.J. Fleet

Journal:

Tetrahedron: Asymmetry

Year:

1996

Language:

english

File:

PDF, 770 KB

english, 1996

24

Synthesis of functionalised cephalosporins : Diphenylmethyl(1S,6R,7S)-3-bromomethyl-7-formamido-7-methoxyceph-3-em-4-carboxylate-1-oxide: a useful intermediate in the preparation of 7α-methoxycephalosporins

K. Biggadike, D.C. Humber, B. Laundon, A.G. Long, M.V.J. Ramsay

Journal:

Year:

1985

Language:

english

File:

PDF, 742 KB

english, 1985

25

3′-deoxy-3′-fluoro-xylo-neplanocin A

Alan D Borthwick, Keith Biggadike

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 253 KB

english, 1992

26

Fluticasone furoate/fluticasone propionate – different drugs with different properties

Keith Biggadike

Journal:

The Clinical Respiratory Journal

Year:

2011

Language:

english

File:

PDF, 82 KB

english, 2011

27

Enzymic glycosylation using 6-substituted glycosides as donor substrates: a novel route to functionalised disaccharides

MacManus, David A., Grabowska, Urszula, Biggadike, Keith, Bird, Michael I., Davies, Stephen, Vulfson, Evgeny N., Gallagher, Timothy

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1999

Language:

english

File:

PDF, 308 KB

english, 1999

28

ChemInform Abstract: Short Synthesis of a Bicyclic Mimic of α-L-Fucose.

A. R. BEACHAM, K. BIGGADIKE, H. E. TAYLOR, L. HACKETT, B. G. WINCHESTER, D. J. WATKIN, G. W. J. FLEET

Journal:

Year:

1995

File:

PDF, 31 KB

1995

29

The effect of a diet containing excess quickly degradable nitrogen (QDN) on reproductive and metabolic hormonal profiles of lactating dairy cows

P.M. Dawuda, R.J. Scaramuzzi, S.B. Drew, H.J. Biggadike, R.A. Laven, R. Allison, C.F. Collins, D.C. Wathes

Journal:

Animal Reproduction Science

Year:

2004

Language:

english

File:

PDF, 123 KB

english, 2004

30

The effect of feeding diets high in quickly degradable nitrogen on follicular development and embryo growth in lactating Holstein dairy cows

R.A Laven, P.M Dawuda, R.J Scaramuzzi, D.C Wathes, H.J Biggadike, A.R Peters

Journal:

Animal Reproduction Science

Year:

2004

Language:

english

File:

PDF, 194 KB

english, 2004

31

Synthesis and Structure−Activity Relationships of Long-acting β 2 Adrenergic Receptor Agonists Incorporating Metabolic Inactivation: An Antedrug Approach

Procopiou, Panayiotis A., Barrett, Victoria J., Bevan, Nicola J., Biggadike, Keith, Box, Philip C., Butchers, Peter R., Coe, Diane M., Conroy, Richard, Emmons, Amanda, Ford, Alison J., Holmes, Duncan

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.07 MB

english, 2010

32

Short convergent route to homochiral carbocyclic-2?-deoxynucleosides and carbocyclic ribonucleosides

Biggadike, Keith, Borthwick, Alan D., Exall, Anne M., Kirk, Barrie E., Roberts, Stanley M., Youds, Peter

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 174 KB

english, 1987

33

The Effect of Increasing Urea Intake in the Lactating Dairy Cow on Follicular Dynamics and Ovulation

RA Laven, HJ Biggadike, CA Collins

Journal:

Acta Veterinaria Scandinavica

Year:

2003

Language:

english

File:

PDF, 57 KB

english, 2003

34

X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain ⊥

Biggadike, Keith, Bledsoe, Randy K., Hassell, Anne M., Kirk, Barrie E., McLay, Iain M., Shewchuk, Lisa M., Stewart, Eugene L.

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 1.43 MB

english, 2008

35

Discovery of a Rapidly Metabolized, Long-Acting β 2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

Procopiou, Panayiotis A., Barrett, Victoria J., Biggadike, Keith, Butchers, Peter R., Craven, Andrew, Ford, Alison J., Guntrip, Stephen B., Holmes, Duncan S., Hughes, Sara C., Jones, Anne E., Looker,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 525 KB

english, 2014

36

A bid to improve station efficiency

Biggadike, Eric, Solts, Keith

Journal:

Year:

2014

Language:

english

File:

PDF, 129 KB

english, 2014

37

Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism

Biggadike, Keith, Angell, Richard M., Burgess, Colin M., Farrell, Rosanne M., Hancock, Ashley P., Harker, Andy J., Irving, Wendy R., Ioannou, Chris, Procopiou, Panayiotis A., Shaw, Rupert E., Solanke,

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 85 KB

english, 2000

38

Fluorocarbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluorocarbocyclic 2'-deoxyguanosines

Borthwick, Alan D., Kirk, Barrie E., Biggadike, Keith, Exall, Anne M., Butt, Suzanne, Roberts, Stanley M., Knight, David J., Coates, Jonathan A. V., Ryan, D. Michael

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.06 MB

english, 1991

39

Novel Glucocorticoid Antedrugs Possessing a 17β-(γ-Lactone) Ring

Procopiou, Panayiotis A., Biggadike, Keith, English, Alan F., Farrell, Rosanne M., Hagger, Graham N., Hancock, Ashley P., Haase, Michael V., Irving, Wendy R., Sareen, Meenu, Snowden, Michael A., Solan

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

40

Designing Corticosteroid Drugs for Pulmonary Selectivity

Journal:

Proceedings of the American Thoracic Society

Year:

2004

Language:

english

File:

PDF, 72 KB

english, 2004

41

Nonsteroidal Glucocorticoid Agonists: Tetrahydronaphthalenes with Alternative Steroidal A-Ring Mimetics Possessing Dissociated (Transrepression/Transactivation) Efficacy Selectivity

Biggadike, Keith, Boudjelal, Mohamed, Clackers, Margaret, Coe, Diane M., Demaine, Derek A., Hardy, George W., Humphreys, Davina, Inglis, Graham G. A., Johnston, Michael J., Jones, Haydn T., House, Dav

Journal:

Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 939 KB

english, 2007

42

Correlation of Skin Blanching and Percutaneous Absorption for Glucocorticoid Receptor Agonists by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging and Liquid Extraction Surface Analysis with Nanoelectrospray Ionization Mass Spectrometry

Marshall, Peter, Toteu-Djomte, Valerie, Bareille, Philippe, Perry, Hayley, Brown, Gillian, Baumert, Mark, Biggadike, Keith

Journal:

Analytical Chemistry

Year:

2010

Language:

english

File:

PDF, 5.15 MB

english, 2010

43

Use of diethylaminosulphur trifluoride (DAST) in the preparation of synthons of carbocyclic nucleosides

Biggadike, Keith, Borthwick, Alan D., Evans, Derek, Exall, Anne M., Kirk, Barrie E., Roberts, Stanley M., Stephenson, Les, Youds, Peter

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1988

Language:

english

File:

PDF, 975 KB

english, 1988

44

Synthesis of fluorinated carbocyclic nucleosides: preparation of carbocyclic 1-(2?-deoxy-6?-fluororibofuranosyl)-5-iodouracils

Biggadike, Keith, Borthwick, Alan D., Exall, Anne M., Kirk, Barrie E., Roberts, Stanley M., Youds, Peter, Slawin, Alexandra M. Z., Williams, David J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1987

Language:

english

File:

PDF, 220 KB

english, 1987

45

Novel glucocorticoid antedrugs possessing a C16,17-fused γ-lactone ring

Biggadike, Keith, Lynn, Sean M., Procopiou, Panayiotis A., Shaw, the late Rupert E., Williamson, Christopher

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2000

Language:

english

File:

PDF, 281 KB

english, 2000

46

Short synthesis of a bicyclic mimic of ?-L-fucose

Beacham, Annabel R., Biggadike, Keith, Taylor, Helen E., Hackett, Lucy, Winchester, Bryan G., Watkin, David J., Fleet, George W. J.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1994

Language:

english

File:

PDF, 246 KB

english, 1994

47

4?-Modification of carbocyclic nucleosides: synthesis of 4?-?-fluoro, 4??-hydroxy and 4?,6?-unsaturated derivatives of the antiviral agent 2?-ara-fluoro carbocyclic guanosine

Biggadike, Keith, Borthwick, Alan D.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1990

Language:

english

File:

PDF, 216 KB

english, 1990

48

2?-Deoxy-2?-fluoro-ara-aristeromycin, a new anti-herpes agent: the first direct introduction of a 2?-fluoro substituent into a carbocyclic nucleoside

Biggadike, Keith, Borthwick, Alan D., Exall, Anne M., Kirk, Barrie E., Ward, Richard A.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1988

Language:

english

File:

PDF, 223 KB

english, 1988

49

Synthesis and enzymatic resolution of carbocyclic 2?-ara-fluoro-guanosine: a potent new anti-herpetic agent

Borthwick, Alan D., Butt, Suzanne, Biggadike, Keith, Exall, Anne M., Roberts, Stanley M., Youds, Peter M., Kirk, Barrie E., Booth, Brian R., Cameron, Janet M., Cox, Susan W., Marr, Clara L. P., Shill,

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1988

Language:

english

File:

PDF, 284 KB

english, 1988

50

Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring

Angell, Richard M., Biggadike, Keith, Farrell, Rosanne M., Flack, Stephen S., Hancock, Ashley P., Irving, Wendy R., Lynn, Sean M., Procopiou, Panayiotis A.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

2002

Language:

english

File:

PDF, 206 KB

english, 2002

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